metabolic regulation.

MOTS-c and Mitochondrial-to-Cell Signaling: Evidence from Experimental Research

Experimental studies of MOTS-c, a mitochondrial-derived peptide, reveal novel mechanisms of mitochondrial-to-cell signaling. This resource reviews the molecular origins, cellular actions, and systemic effects of MOTS-c in laboratory and animal models, highlighting its role in metabolic regulation and the current limitations of the evidence.