behavioral endpoints.

Elevated Plus Maze Endpoints in Selank Rat Studies: Research Interpretation

The elevated plus maze (EPM) is a validated behavioral assay for assessing anxiety-like behaviors in rodents. In Selank rat studies, EPM endpoints—such as time spent in open versus closed arms—serve as quantitative measures of anxiety, not direct clinical outcomes. This article reviews the experimental design, measured endpoints, and interpretation of EPM data in the context of Selank research, emphasizing methodological strengths, limitations, and the boundaries of preclinical inference.